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Watch Intently (one)lumefantrine will lessen the level or influence of exemestane by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe. For clients obtaining exemestane that has a potent CYP3A4 inducer the recommended dose of exemestane is 50 mg day-to-day after a meal.Plan evaluation of twenty five-hydroxy vitamin D amou